Organolithium mediated synthesis of prenylchalcones as potential inhibitors of chemoresistance

Article abstract of DOI:10.1016/S0040-4039(99)01461-6

A number of substituted chalcones have been prepped by a novel LiHMDS- mediated aldol condensation, the first method consistent with the use of alkali-labile protecting groups such as tert-butyldiphenylsilyl or tert- butyldimethylsilyl. Chalcone substitution by prenylation increases their binding affinity to P-glycoprotein responsible for cancer cells chemoresistance.