ACCURATE DETERMINATION OF THE INTRINSIC RACEMIZATION IN CHIRAL SYNTHESIS VIA ENANTIOMER RESOLUTION OF UNDERIVATIZED VICINAL DIOLS

Article abstract of DOI:10.1016/S0040-4039(01)93460-4

The accurate assessment of the intrinsic racemization (down to 0.01percent), inherent to reactions typically applied in chiral synthesis, demands for (i) a precursor of almost 100percent e.e. (e.g., S-1a, e.e. >=99.99percent), and (ii) a reliable method for the determination of e.e. of the product (e.g., the derivatization-free enantiomer resolution of the vicinal diol 3a by GC on Chirasil-Val).