Design of resolving reagents: p-substituted mandelic acids as resolving reagents for 1-arylalkylamines

Article abstract of DOI:10.1016/0957-4166(96)00175-9

The resolution of 1-arylalkylamines 2-10 by mandelic acid 1 was studied. It was found that a substituent, which elongated the molecular length of the amines, diminished the resolution efficiency. On the basis of these results, (S)-p-methylmandelic acid (S)-11 and (R)-p-methoxymandelic acid (R)-12 were selected as new resolving reagents for the 1-arylalkylamines; these acids were found to have a higher resolving ability than (R)-1.