A New Stereocontrolled Route to trans-2,5-Disubstituted Tetrahydrofurans

Article abstract of DOI:10.1246/cl.1992.195

An effective new route for the stereocontrolled synthesis of trans-2,5-disubstituted tetrahydrofurans was described, which involved a new type of 1,4-asymmetric induction based on the addition of originally designed dithianyl anion to aldehydes and a stereocontrolled cyclodehydration of the resulting 1,4-diols.