A mild and effective iodination method using iodine in the presence of bis-(trifluoroacetoxy)iodobenzene

Article abstract of DOI:10.1016/S0040-4039(98)01494-4

Herein is described a mild and effective iodination method using bis(trifluoroacetoxy)iodobenzene iodine as reagent to be applied to electron deficient heterocyclic systems (protected indoles coumarin...). Moreover, sensitive protecting groups such as acetyl and tert butyldimethylsilyl were found to be stable under the new iodination reaction conditions.