Bioorganic and Medicinal Chemistry Letters p. 2903 - 2906 (1998)
Update date:2022-08-18
Topics:
Chan, Wai N.
Hadley, Michael S.
Harling, John D.
Herdon, Hugh J.
Jerman, Jeffrey C.
Orlek, Barry S.
Stean, Tania O.
Thompson, Mervyn
Upton, Neil
Ward, Robert W.
A series of N-(tetrahydroisoquinolinyl)-2-methoxybenzamides was identified by high-throughput screening at the novel SB-204269 binding site. SAR studies have provided compounds 4 and 14 with high affinity and good anticonvulsant activity in animal models.
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