Cerium(IV) oxidations of β-aminoketones, VIII: Synthesis of 1,2,3,4-tetrahydroisoquinolines with differently substituted piperidine parts

Article abstract of DOI:10.1002/ardp.19933260406

1- and 3-Alkyl- and/or aryl substituted tetrahydroisoquinolines are obtained by oxidative cyclisation of N-benzyl-β-aminoketones with cerium(IV) sulphate. In nearly all cases formation of mixtures of diastereomeres is observed. If the ketone function is r