Oxidation of the methyl groups of N,N-dimethylbenzamides by a cytochrome P450 monooxygenase model system

Article abstract of DOI:10.1016/S0040-4039(00)97769-4

Oxidation of N,N-dimethylbenzamides to the corresponding N,N-formyl-N-methylbenzamides using tetraphenylporphyrinato-iron(III)-Bu^tOOH is independent of the substituent in the aryl ring of the benzamide group and subject to a kinetic deuterium isotope effect of 5.6. These results are consistent with a mechanism involving direct hydrogen atom abstraction from the substrate.