Journal of Physical Chemistry p. 4718 - 4722 (1991)
Update date:2022-08-11
Topics:
Zhang, Nan
Schuchmann, Heinz-Peter
Sonntag, Clemens von
The radical-induced oxidation of dithiothreitiol (DTT) by O2 to 4,5-dihydroxy-1,2-dithiane (ox-DTT) in aqueous solutions of pH 8.7 proceeds via a chain reaction.Radicals such as OH generated by the radiolysis of N2O/O2-saturated aqueous solutions abstract an H atom from DTT.The resulting DTT(-H). radicals cyclize and deprotonate, yielding the disulfide radical anion ox-DTT.-.The latter reacts with O2 (k = 7.1 x 108 dm3 mol-1 s-1) giving rise to ox-DTT and O2.-.The G value of ox-DTT formation increases with decreasing dose rate, displaying a linear yield vs (dose rate)1/2 relationship indicative of a chain reaction.The chain is inhibited by superoxide dismutase, showing that 02.- is a chain carrier.Hydrogen peroxide is not a chain product, from which it is concluded that O2.- does not abstract hydrogen from DTT but rather forms a short lived complex with the DTT anion which then predominantly decomposes into an RSO. radical and an OH- ion, (and to a lesser extent into an OH radical and an RSO- ion).In a second step, the RSO. radical reacts with DTT (probably the anionic form DTT-), thus regenerating DTT(-H)..The resulting sulfenic acid eliminates water and yields the chain product ox-DTT.An overall propagation rate constant of 35 dm3 mol-1 s-1 has been estimated.
View Morejiangsu senxuan pharmaceutical and chemical co.,ltd
Contact:86-523-87982810
Address:hongqiao industrial zone,taixing,jiangsu china
Contact:+86-22-83718541
Address:32th Floor, Rongqiao Center Intersection of Changjiang Road and Nankai Six Road Nankai District Tianjin 300102, China
Yingkou Sanzheng Organic Chemical Co. Ltd.
Contact:+86-417-3638818
Address:25 Gengxinli Village, Daqing Road, Yingkou, Liaoning, China
Contact:+86-371-55981030
Address:Room 1571, Macalline Soho, No.1, Shangdu Road, Zhengzhou, Henan
Yibin Hope Pharmaceutical Co., Ltd.
Contact:+86-831-5109851 86-831-5109836
Address:Luolong Industrial Zone,Nanxi, Yibin City, Sichuan, China. | Email: wishmarketing@gmail.com | Website: http://www.hopepharma.cc/
Doi:10.1016/S0045-6535(99)00261-1
(2000)Doi:10.1021/ja00393a031
(1981)Doi:10.1039/c9cc02866h
(2019)Doi:10.1016/S0022-328X(00)99347-1
(1986)Doi:10.1063/1.2916705
(2008)Doi:10.1002/jsde.12050
(2018)