Tetrahedron Letters p. 2413 - 2416 (1992)
Update date:2022-08-12
Topics:
Mamos
Van Aerschot
Weyns
Herdewijn
A one step synthesis of the 8-methyl-, 8-ethyl- and 8-vinyl derivatives of adenosine, 2'-deoxyadenosine and 2',3'-dideoxyadenosine starting from the readily available 8-bromo congeners is described. This reaction makes use of a transient silylation procedure and a Pd(0) catalysed cross-coupling with tetraorganotin reagents.
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