A new C2-symmetric heterobimetallic complex as a promoter for asymmetric Michael addition reactions

Article abstract of DOI:10.1016/S0957-4166(97)00234-6

A C2-symmetric chiral amino diol (1R,5R)-3-aza-3-benzyl-1,5-diphenyl pentan-1,5-diol [(R,R)-I] has been synthesised by a modified procedure. The heterobimetallic catalyst [I₂-AI-Li] obtained by reaction of the amino diol [(R,R)-I] with LiAlH₄, promotes asymmetric Michael addition of malonic esters and thiophenols to α,β-unsaturated compounds with high enantiomeric excess.