The synthesis of 6,6,6-2H3-2E-hexenal

Article abstract of DOI:10.1002/jlcr.2580340214

6,6,6-²H₃-2E-Hexenal, leaf-aldehyde, has been synthesised in 45% yield and 99.3% purity by reaction of 3,3,3-²H₃-n-propyl magnesium bromide with an ethereal solution of 3-trimethylsiloxy-2-propenal (3) prepared in situ. This new one pot procedure alleviates the need to isolate (3) and should prove useful in the synthesis of other E-α,β-unsaturated aldehydes.