Bioorganic and Medicinal Chemistry Letters p. 5247 - 5250 (2004)
Update date:2022-08-30
Topics:
Reigan, Philip
Gbaj, Abdul
Chinje, Edwin
Stratford, Ian J.
Douglas, Kenneth T.
Freeman, Sally
A series of xanthine oxidase-activated prodrugs of known inhibitors of thymidine phosphorylase are described. These prodrugs were oxidised by xanthine oxidase at C-2 and/or C-4 of the uracil ring to generate the desired TP inhibitor. The scheme shows the prodrug of TPI. A series of xanthine oxidase-activated prodrugs of known inhibitors of thymidine phosphorylase has been designed and synthesised to introduce tumour selectivity. These prodrugs were oxidised by xanthine oxidase at C-2 and/or C-4 of the uracil ring to generate the desired TP inhibitor.
View MoreShandong Bolode Bio-Technology Co., LTD
Contact:+86-0531-58966870
Address:136 Jingyi Road,Huaiyin District,Jinan,Shandong,China
Contact:0086-22-23410962
Address:17-201, Ningfuli, Shuishanggongyuandong road,Nankai district, Tianjin, China
Contact:+49-9398-993127
Address:Untertorstr. 27
Hangzhou LINGEBA Technology Co., Ltd.
Contact:+0086-571-87389059
Address:Office 1-913,NewYouth Plaza, GongShu Area, HangZhou,ZheJiang,P.R.China
Wuxi Innopal International Trade CO.,LTD
Contact:+86-510-80711901-8003
Address:Room 402,Building 5,Longze Garden,No.17,South huanjiu Road,Yixing City, Jiangsu,China
Doi:10.1021/j100382a036
(1990)Doi:10.1016/j.freeradbiomed.2010.10.709
(2011)Doi:10.1021/ja00236a009
(1987)Doi:10.1021/ja01313a018
(1935)Doi:10.1080/00397910903219427
(2010)Doi:10.1039/c5ra03062e
(2015)