REMOVAL OF N-BENZYL- AND N-BENZYLOXYMETHYL SUBSTITUENTS FROM SUBSTITUTED URACILS WITH BORON TRIBROMIDE

Article abstract of DOI:10.1016/S0040-4039(01)83926-5

N1,N3-Dibenzyl uracil derivatives have been successfull deblocked by using boron tribromide in refluxing xylene.Also, N1,N3-dibenzyloxy methyl uracil derivatives can be easily converted to uracils by treatment with boron tribromide in benzene in the cold and subsequent boiling of the intermediate with water.