Implementation of a combinatorial cleavage and deprotection scheme. 1. Synthesis of phthalhydrazide libraries

Article abstract of DOI:10.1016/0040-4039(96)00544-8

Phthalhydrazide libraries are synthesized in solution from substituted hydrazines and phthalimides in several different library formats including single compounds, indexed sub-libraries and a full library. When carried out during solid-phase synthesis, this combinatorial cleavage and deprotection scheme offers the possibility for generating a diverse library of substituted phthalhydrazides. Copyright