MedChemComm p. 1498 - 1504 (2017)
Update date:2022-08-17
Topics:
Li, Bo
Yang, Yongan
Chen, Liuzeng
Chen, Shichao
Zhang, Jing
Tang, Wenjian
Based on the SAR analysis of glycyrrhizin, 18α-glycyrrhetinic acid monoglucuronide (18α-GAMG) with strong inhibition against LPS-induced NO and IL-6 production in RAW264.7 cells was discovered. Western blotting and immunofluorescence results showed that 18α-GAMG reduced the expression of iNOS, COX-2, and MAPKs, as well as activation of NF-κB in the LPS-stimulated RAW264.7 cells. Further in vivo results showed that 18α-GAMG could significantly improve the pathological changes of CCl4-induced hepatic fibrosis.
View MoreGuilin Zhenda Bio-Tech Co., Ltd.
Contact:86-773-3568977
Address:-Yangtang shangshui industry park, Lingui county,
website:http://www.herbpurify.com
Contact:0086-028-85249238
Address:Room709-C1,Incubator Building, Tianfu Life Science Park No.88,Keyuan Road,Gaoxin district,Chengdu City,Sichuan Prov,China
Shanghai Potomer International Trade CO., LTD
Contact:+86-21-61397128
Address:Room 304,No.505 ,Caoyang Road.Shanghai,China
Contact:+86-15527136576
Address:Wuhan city
XI'AN CHUKANG BIOTECHNOLOGY CO.,LTD
Contact:29-63685658 63685359
Address:Room 3-1202,Building 1,Oriental oasis,East of Xianning Road,Xi'an,Shaanxi 710043 P.R.China
Doi:10.1039/c5nj00405e
(2015)Doi:10.1002/jccs.200700142
(2007)Doi:10.1002/hlca.19470300715
(1947)Doi:10.1016/j.jcat.2007.11.008
(2008)Doi:10.1016/j.bmcl.2005.11.005
(2006)Doi:10.1021/ol5013668
(2014)