European Journal of Medicinal Chemistry p. 232 - 243 (2016)
Update date:2022-08-16
Topics:
Han, Xuan
Luo, Jiang
Wu, Feng
Hou, XueYan
Yan, Guoyi
Zhou, Meng
Zhang, Mengqi
Pu, Chunlan
Li, Rui
In this study, a series of novel molecules containing chromeno [3,4-d] imidazol-4(1H)-one was synthesized and their biological activities were evaluated. Among them, compound 35 showed a dramatic anticancer activity against HCT116 and MCF-7, and the flow cytometry assays demonstrated that it could arrest G0/G1 cell-cycle and induce apoptosis of SW620 cells in a dose-dependent manner. Besides, it also blocked MCF-7 cancer cell migration. Moreover, it inhibited tumor growth in HCT116 subcutaneously implanted xenografted mice. Taken together, compound 35 may be a promising candidate for anti-cancer agent as well as metastatic one.
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Doi:10.1021/ic50044a001
(1966)Doi:10.1016/j.polymer.2014.04.003
(2014)Doi:10.1023/B:CONC.0000025473.93772.9e
(2004)Doi:10.1246/bcsj.40.2214
(1967)Doi:10.1021/ja01494a077
(1960)Doi:10.1016/S0040-4020(02)01588-0
(2003)