
Helvetica Chimica Acta p. 731 - 737 (1989)
Update date:2022-08-11
Topics:
Deschenaux, Pierre-Francois
Kallimopoulos, Thomas
Stoeckli-Evans, Helen
Jacot-Guillarmod, Andre
The two enantiomers (-)-(2S)- and (+)-(2R)-6-ethyl-3,4-dihydro-2-methyl-4-oxo-2H-pyran-5-carboxylic acid ((S)- and (R)-7) have been synthesized from (+)-(3S) and (-)-(3R)-3-hydroxybutanoates, respectively (Scheme 1).By reduction and decarboxylation, the tetrahydro-2H-pyranols (2R,4R,6S)- and (2S,4S,6R)-13, respectively, were obtained with an enantiomeric excess of >/= 93 percent.
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