Synthesis soluble non-ion transition metal manganese(II), cobalt(II), nickel(II) complexes of diethylenetriamine-N,N′,N″-tri(acetyl-p-hydroxybenzoyl hydrazine)- N,N″- bisacetic acid as potential contrast enhancement agent

Article abstract of DOI:10.1080/15533174.2013.831895

A novel ligand, diethylenetriamine-N,N′,N″-tri(acetyl-p-hydroxybenzoyl hydrazine)-N,N″-bisacetic acid, and its three soluble non-ion transition metal complexes, ML· nH₂O (M = Mn, n = 4; M = Co, Ni, n = 2) have been synthesized and characterized on the basis of elemental analysis, molar conductivities, ¹H NMR, FAB-MS, TG-DTA analysis, and IR methods. In addition, relaxivity of complexes are determined, The relaxivity (R₁) of MnL, CoL, NiL, and Gd(DTPA)^2- used as control are 6.33, 2.71, 2.60, and 4.34L·mmol^-1·s^-1, respectively. The spin-lattice relaxivity of MnL are larger than that of Gd(DTPA)^2-. The results showed that complex of MnL may be a potential MRI contrast agent with high spin-lattice relaxivity, good solubility, low osmotic pressure due to non-ion complex.