Synthetic Communications p. 4467 - 4472 (2009)
Update date:2022-08-29
Topics:
Kim, Misoo
Han, Ki-Jong
A simple and convenient method for the synthesis of N-hydroxysuccinimide ester is developed using triphosgene as an acid activator. Several aromatic and aliphatic N-hydroxysuccinimide esters are prepared from their corresponding carboxylic acids at room temperature in good yields in a rapid process using triphosgene. Some of the major advantages are mild conditions, good yields, and easy operation.
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