Simple one step syntheses of indole-3-acetonitriles from indole-3-carboxaldehydes

DOI: 10.3987/com-97-s(n)38

Source and publish data:

Heterocycles p. 509 - 516 (1998)

Update date:2022-08-17

Topics:

Authors:

Yamada, Fumio

Hashizume, Tomoko

Somei, Masanori

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Article abstract of DOI:10.3987/com-97-s(n)38

One step conversion method of indole-3-carboxaldehydes into indole-3-acetonitriles is developed. Applying the method, 4-nitro- (7 a), 4-phenyl-(7 b), 4-iodo- (7 c), 4-methoxy- (7 d), and 4-benzyloxyindole-3-acetonitrile (7 e) are available in two steps from indole-3-carboxaldehyde (4).

Full text of DOI:10.3987/com-97-s(n)38

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