Chemical and pharmaceutical bulletin p. 566 - 567 (2000)
Update date:2022-08-29
Topics:
Umehara
Matsumoto
Nakamura
Miyase
Kuroyanagi
Noguchi
In the course of searching for differentiation inducers against leukemic cells from plants, we have recognized the differentiation inducing activities of the methanolic extract of Hydrangea Dulcis Folium. Activity guided separation of the extract was carried out using M1 cells, and seven isocoumarins were isolated as active substances. These isocoumarins showed the activities at the concentration of 100 microM and non-cytotoxic effects even at 300 microM.
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