SYNTHESIS OF TYROCIDINE A: USE OF OXIME RESIN FOR PEPTIDE CHAIN ASSEMBLY AND CYCLIZATION

Article abstract of DOI:10.1016/S0040-4039(00)97003-5

Application of the Kaiser oxime resin to the synthesis of the thirty-membered ring cyclo-decapeptide Tyrocidine A (TA) is described.Assembly of the linear peptide chain and its subsequent cyclization with concominant cleavage off the solid support were both achieed in high yield (73.2 and 55percent).