Photodecomposition of CI-981, an HMG-CoA reductase inhibitor

Article abstract of DOI:10.1016/S0040-4020(01)86297-9

Upon exposure to intense simulated sunlight, CI-981 (1) readily decomposes into three major by-products. This paper reports on the products formed when 1 is decomposed in acetonitrile/water solutions under intense simulated sunlight, ultraviolet light filtered at 254 nm and visible light. Included is a discussion of the isolation of the major by-products and possible mechanisms for the photooxidative processes which lead to them.