N-tert-butoxycarbonyl (BOC) deprotection using boron trifluoride etherate

Article abstract of DOI:10.1080/00397919708006783

A mild and efficient procedure is described for the removal of the tert- butoxycarbonyl (BOC) group using boron trifluoride etherate and molecular sieves in dichloromethane at room temperature. The scope of this procedure is explored for the deprotection of a variety of amines including amino acid derivatives.

Full text of DOI:10.1080/00397919708006783

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Synthetic Communications: An
International Journal for Rapid
Communication of Synthetic
Organic Chemistry
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N-tert-Butoxycarbonyl (BOC)
Deprotection Using Boron
Trifluoride Etherate
a
b
Emily F. Evans , Norman J. Lewis , Isabelle Kapfer
a
a
a
,
Gregor Macdonald & Richard J. K. Taylor
a
Department of Chemistry , University of York ,
Heslington, York, YO1 5DD, UK
b
SmithKline Beecham Pharmaceuticals , Leigh,
Tonbridge, Kent, TN11 9AN, UK
Published online: 22 Aug 2006.
To cite this article: Emily F. Evans , Norman J. Lewis , Isabelle Kapfer , Gregor
Macdonald & Richard J. K. Taylor (1997) N-tert-Butoxycarbonyl (BOC) Deprotection
Using Boron Trifluoride Etherate, Synthetic Communications: An International Journal
for Rapid Communication of Synthetic Organic Chemistry, 27:11, 1819-1825, DOI:
10.1080/00397919708006783
To link to this article: http://dx.doi.org/10.1080/00397919708006783
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