Solid phase synthesis of alkenes using the Horner-Wadsworth-Emmons reaction and monitoring by gel phase 31P NMR

Article abstract of DOI:10.1016/0040-4039(95)02017-J

Phosphonoacetamide esters bound to solid supported peptides or peptide synthesis supports are active as Horner-Wadsworth-Emmons (HWE) reagents with a variety of aldehydes. HWE reagents can be attached to the solid support via the amide or phosphono ester. Mild basic conditions, triethylamine and Li salts, with excess aldehyde give high conversions to alkenes.