Journal of Organic Chemistry p. 20 - 24 (1980)
Update date:2022-08-28
Topics:
Alexander, Jose
Bhatia, Ashok V.
Mitscher, Lester A.
Omoto, Shoji
Suzuki, Toshio
The chemistry of aloe-emodin (3) has been explored with a view toward its use as a synthon for the regiospecific synthesis of adriamycin and analogues of it.Routes for satisfactory large-scale monomethyl ether formation at C8 (4) and regiospecific introduction of a phenolic oxygen function at C4 (21) are described.Interesting side reactions were encountered, including an apparent peri O to O acyl wandering reaction during methylation and a reductive debromination reaction during displacement of an aryl bromide by methanolic methoxide.
View MoreShanghai Hanshare Industry Co.,Ltd.
Contact:86 21 20960688
Address:RM902-903,Building E, Wanda Plaza,No.26,Zhoukang Road, Pudong District, Shanghai, China
website:http://www.tcfinechem.com/
Contact:18681346930
Address:baifu town,whou district
Changyi Xinxing Technology Development Co., Ltd.
Contact:0086-510-86651065(Time Zone:8),86651656
Address:94 Yingbinxilu WestRoad, Huangtu Town, Jiangyin City, Jiangsu, China
Wuxi Innopal International Trade CO.,LTD
Contact:+86-510-80711901-8003
Address:Room 402,Building 5,Longze Garden,No.17,South huanjiu Road,Yixing City, Jiangsu,China
Contact:+86-571-86025531 / 86024803
Address:1218-24 Guangyin Mansion,42 Fengqi East Road
Doi:10.1021/jacs.0c04695
(2020)Doi:10.1016/j.saa.2020.119154
(2021)Doi:10.1002/anie.201403793
(2014)Doi:10.1021/acs.orglett.9b03590
(2019)Doi:10.1016/j.bioorg.2018.11.044
(2019)Doi:10.1124/dmd.119.086892
(2019)