Studies on chiral thiophosphoric acids and their derivatives 16. - The asymmetric cyclization of L-(+)-prolinol with (thio)phosphoro(-no)dichloridates

Article abstract of DOI:10.1080/10426509708040496

The cyclizations of L-(+)-prolinol 5 with (thio)phosphoro(-no)dichloridates 6 give 1,2,3-azaphosphaoxabicyclo[3.3.0]octanes 7 consisting of unequal amounts of diastereoisomers, eight pairs of which have been successfully resolved by silica gel column chromatography or recrystallization. The influences of reaction temperature, solvent and substrate concentration upon the asymmetric induction have also been investigated.

Full text of DOI:10.1080/10426509708040496

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Phosphorus, Sulfur, and Silicon and the
Related Elements
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STUDIES ON CHIRAL THIOPHOSPHORIC
ACIDS AND THEIR DERIV ATIVES 16.-THE
ASYMMETRIC CYCLIZATION OF L-(+)-
PROLINOL WITH (THIO)PHOSPHORO(-
NO)DICHLORIDATES
Zheng-Jie He a , You-Ming Wang a & Chu-Chi Tang a
a State Key Laboratory of Elemento-Organic Chemistry , Nankai
University , Tianjin, 300071, P. R. China
Published online: 04 Oct 2006.
To cite this article: Zheng-Jie He , You-Ming Wang & Chu-Chi Tang (1997) STUDIES ON CHIRAL
THIOPHOSPHORIC ACIDS AND THEIR DERIV ATIVES 16.-THE ASYMMETRIC CYCLIZATION OF L-(+)- PROLINOL
WITH (THIO)PHOSPHORO(-NO)DICHLORIDATES, Phosphorus, Sulfur, and Silicon and the Related Elements,
127:1, 59-66, DOI: 10.1080/10426509708040496
To link to this article: http://dx.doi.org/10.1080/10426509708040496
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