Effect of metal counterions on the stereoselectivity of aldol reactions used to assemble the seco acid backbone of erythromycin b

Article abstract of DOI:10.1016/S0040-4039(00)73542-8

The diastereofacial selectivity of the aldol reactions of the enolates derived from the ketones 11, 15, and 19 with the aldehyde 2a depended upon whether the counterion was lithium or titanium. For lithium enolates the stereoselectivity appeared to be con