Tetrahedron Letters p. 2497 - 2500 (1999)
Update date:2022-08-11
Topics:
Hengeveld, John E.
Gupta, Ashok K.
Kemp, Anne H.
Thomas, Albert V.
4-Deoxyerythromycin B reacts with 1-chloroethyl chloroformate to give the corresponding N-demethyl N-chloroethyl carbamate. Mild methanolysis removes the chloroethyl group giving the N-demethyl erythromycin derivative while also forming the 6,9-enol ether moiety. Further manipulation gives ABT- 229, a potential prokinetic agent.
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Doi:10.1039/a808468h
(1999)Doi:10.1039/c7ra07907a
(2017)Doi:10.1002/jhet.583
(2011)Doi:10.1039/ft9908604077
(1990)Doi:10.1039/c9ra03316e
(2019)Doi:10.1021/acs.orglett.6b02735
(2016)
