Enantiopure p,p'-disubstituted 1,2-diphenylethane-1,2-diols as chiral inducers in the Ti-mediated oxidation of sulfides: A case of reversal of asymmetric induction by fluorine substitution

Article abstract of DOI:10.1016/S0040-4039(98)01907-8

In the asymmetric oxidation of methyl p-tolyl sulfide, (2a), and benzyl phenyl sulfide (2b) by TBHP, mediated by a titanium complex with enantiopure (R,R)-p,p'-disubstituted-1,2-diphenylethane-1,2-diols, both the unsubstituted diol (R,R)-1a and the p-OMe