Synthesis of nucleoside α-hydroxy phosphonates

Article abstract of DOI:10.1016/S0040-4039(00)73794-4

Nucleophilic addition of a dialkyl phosphite anion to 2′- or 3′-keto nucleosides results in an efficient synthesis of 2′-hydroxy-2′-phosphono- or 3′-hydroxy-3′-phosphononucleosides. The stereochemistry of one such adduct, 5′-O-trityl-3′-β-hydroxy-3′-α-(di