Synthetic studies on N-acetyl derivatives of amino acids and thiolactone using Vilsmeier-haack reagent

Article abstract of DOI:10.1016/S0040-4039(00)60540-3

A variety of N-acetyl derivatives of amino acids have been subjected to Vilsmeier reagent to obtain 2,4-dichloro-3,5-diformylpyrrole and 2-formylmethylene-4-substituted oxazolidin-5-ones. The N-acetyl homo cysteine thiolactone gave 5-chloro-3-formylthieno (2,3-b)pyridine on reaction with Vilsmeier reagent.