Copper(II) chloride as an efficient reagent for the dehydrogenation of pyridazinone derivatives

DOI: 10.1055/s-1995-4079

Source and publish data:

Synthesis p. 1240 - 1242 (1995)

Update date:2022-08-11

Topics:

Authors:

Csende Csende

Szabo Szabo

Bernath Bernath

Stajer Stajer

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Article abstract of DOI:10.1055/s-1995-4079

A new procedure is described for the preparation of pyridazinones from 4,5-dihydropyridazinones under mild conditions with CuCl₂ in MeCN via halogenation and spontaneous HCl elimination. For the trans-hexahydrophthalazin-8(1H)-one 1B*, the HCl elimination is five times faster than for the corresponding cis isomer 1B.

Full text of DOI:10.1055/s-1995-4079

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