Tetrahedron Asymmetry p. 351 - 355 (1998)
Update date:2022-08-17
Topics:
Adam, Waldemar
Lazarus, Michael
Saha-Moeller, Chantu R.
Schreier, Peter
The enzymatic resolution of chiral 2-hydroxy acids 1 by enantioselective oxidation with molecular oxygen in the presence of glycolate oxidase from spinach (Spinacia oleracea) and subsequent asymmetric reduction of 2-oxo acids 2 with D-lactate dehydrogenase from Lactobacillus leichmannii leads to enantiomerically pure (R)-2-hydroxy acids in up to 89% yield based on the racemate.
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