Kinetic and mechanistic characterization of an efficient hydrolytic antibody: Evidence for the formation of an acyl intermediate

Article abstract of DOI:10.1021/ja00093a002

In this paper we report the generation and mechanistic characterization of an unusually active catalytic antibody raised to a phosphonate transition-state analog of norleucine. The antibody (17E8) catalyzes the hydrolysis of both norleucine and methionine