Synthesis of some 2-C-alkyl-2,3-dideoxy-α,β-L-glycero-tetrurono-1,4-lactones. Evaluation as antitumor agents

Article abstract of DOI:10.1016/0008-6215(94)80067-7

A series of 3-C-alkyl-2,3-dideoxy-5-O-trityl-D-erythro-pentono-1,4-lactones were detritylated.The resultant free-hydroxy compounds were converted to their respective 2-C-alkyl-2,3-dideoxy-α,β-L-glycero-tetrurono-1,4-lactones (L-sugar numbering) in a one-v