Tetrahedron p. 565 - 570 (1996)
Update date:2022-08-11
Topics:
Kawanami, Yasuhiro
Moriya, Hitoko
Goto, Yuka
Tsukao, Keiko
Hashimoto, Michihiro
Enantioselective preparation of C2-symmetric (-)-(2S,5S)-N-benzyl-trans-2,5-bis(acetoxymethyl)pyrrolidine was carried out by the lipase-catalyzed hydrolysis of racemic diacetate. Organic co-solvent affected the enantioselectivity and 50% DMSO in the phosphate buffer was found to be the optimal solvent system. A possible active site model was also described.
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