Bioorganic and Medicinal Chemistry Letters p. 1117 - 1122 (1998)
Update date:2022-08-04
Topics:
Mantegani, Sergio
Brambilla, Enzo
Caccia, Carla
Damiani, Gabriele
Fornaretto, Maria Gioia
McArthur, Robert A.
Varasi, Mario
Novel classes of 13- and 14-tertbutyl-ergoline derivatives were prepared, and characterised in vitro for their affinity for adrenergic, dopaminergic and serotonergic binding sites. This study particularly examines the importance of the presence and the position of the tert-butyl group in conferring either significant 5-HT(1A) or 5-HT2 affinity and selectivity respectively.
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