SYNTHESE EN SERIE ENCOMBREE. PREPARATION DE L'ACIDE DITERTIOBUTYL-METHYLACETIQUE tBu2MeCCOOH ET DE QUELQUES COMPOSES CETONIQUES DERIVES DE CETTE STRUCTURE

Article abstract of DOI:10.1016/0040-4020(81)85010-7

The synthesis of ^tBu2MeCCOOH, which is among the most sterically hindered known acids is described.Only Newman's sequence via ^tBu2C=O, ^tBu2MeCOH, ^tBu2C=CH2, ^tBu2CHCH2OH, ^tBu2CHCOOH, ^tBu2CHCOCl and ^tBu2C=C=O, which has been optimized in this work by a direct access to ^tBu2CHCOOH, permits the preparation of ^tBu2MeCCOOH.The condensation of the corresponding chloride with a Grignard reagent yields new highly-hindered ketones ^tBu2MeCCOR wich by alkylation give more substituted structures.The limitations of each method have been studied in this work.