Design, Synthesis and Potential Use of 3,9-Substituted Xanthene Handles for Solid Phase Peptide Synthesis

Article abstract of DOI:10.1002/prac.19943360509

Theoretical calculations on different xanthene derivatives and related structures were performed and as a result conclusions could be drawn for the acid-lability of substituted xanthenes. (9-Hydroxyxanthene-3-oxy)acetic- and valeric acid (6a and 6b) were selected, synthesized in a six-step route, and 6b was tested for its applicability as a handle for solid phase synthesis of peptides.