Synthesis p. 771 - 772 (1993)
Update date:2022-08-11
Topics:
Sicker
Hartenstein
A series of naturally occurring hemiacetals 2a-d was synthesized by the chemoselective diisobutylaluminum hydride reduction of 2,3-dioxo-4H-1,4-benzoxazines 1a,b and their N-hydroxy derivatives 1c,d precursors. The procedure described represents a new general approach to the 2-hydroxy-2H-1,4-benzoxazin-3(4H)-one skeleton giving rise to the bioactive natural hydroxamic acids 2,4-dihydroxy-2H-1,4-benzoxazin-3(4H)-one (2c) and 2,4-dihydroxy-7-methoxy-2H-1,4-benzoxazin-3(4H)-one (2d) in only three steps starting from nitrophenols.
View MoreJiangxi Dongxu Chemical Science & Technology Co.,Ltd
Contact:+86-791-86899381
Address:Nanchang, Jiangxi, China
Linyi Shengxin Pharmaceutical R&D Co., Ltd
Contact:+86-18653953873
Address:West First of Yufeng Road, Yishui County
Zhejiang kehong chemical co., ltd
Contact:0086-575-85522000
Address:xiner center RD binhai industrial zone shaoxing zhejiang province P.R.China,312073
Hangzhou jls Flame Retardants Chemical Co.,Ltd
Contact:+86-571-87250387/87250386
Address:MOGANSHAN RODA 1418# SHANGCHENG INDUSTRIAL PARK
Jinan Jianfeng Chemical Co., Ltd
Contact:0086-531-88110457
Address:sales01(-a-t-)pharmachemm{dot}c+o+m
Doi:10.1021/jo01269a115
(1968)Doi:10.1021/jo00187a034
(1984)Doi:10.1007/s11172-010-0283-0
(2010)Doi:10.1002/pola.27465
(2015)Doi:10.1002/bkcs.10435
(2015)Doi:10.1021/cs501030f
(2014)