Synthesis of 1,4-dihydro-4-oxypyridazino[1,6-a]indole-3-carboxylic acids and 1,4-dihydro-4-oxopyrido[3',2':4,5]pyrrolo[1,2-b]-pyridazine-3-carboxyl ic acids as potential antibacterial agents

Article abstract of DOI:10.1002/jhet.5570310648

A few aza analogues of the quinolones have been prepared in the two milies of the 1,4-dihydro-4-oxopyridazino[1,6-a]indole-3-carboxylic acids and the 1,4-dihydro-4-oxopyrido[3',2':4,5]pyrrolo[1,2-b]pyridazine-3-carboxyli c acids to check their antibacterial potential. One compound 6c shows antibacterial activities of the level of nalidixic acid and represents a new lead structure differing from the classical quinolones.