A New Fluorene-Derived Anchor for Solid-Phase Synthesis of Protected Peptides

Article abstract of DOI:10.1016/S0040-4039(00)91730-1

N-<9-(hydroxymethyl)-2-fluorenyl> succinamic acid may be used as an anchoring linkage for the preparation of protected peptide segments in combination with Boc/Bzl protection scheme.The new handle proved to be stable to the usual conditions of solid-phase peptide synthesis and gave the protected peptide in high yields and purities by treatment with piperidine or morpholine.