Dimerization of substituted 2-aminobenzoic acids under Vilsmeier conditions: A novel route to the synthesis of 4-(3H)-quinazolinones

Article abstract of DOI:10.1016/0040-4039(96)01022-2

Various substituted 2-aminobenzoic acids on treatment with Vilsmeier reagent (DMF/POCl₃) at 80-90°C undergo a novel dimerization reaction to yield 2-[3,4-dihydro-4-oxo-3-quinazolinoyl]-N,N-dimethyl benzamides. The interruption of dimerization a