Titanium mediated reductive amination on solid support: Extending the utility of the 4-hydroxy-thiophenol linker

Article abstract of DOI:10.1016/S0040-4039(98)01876-0

The solid supported synthesis of a library of 8,448 benzopyrans was accomplished using the 4-hydroxythiophenol react and release linker. Reductive aminations were performed in parallel using a Ti(OiPr)₄/Na(OAc)₃BH reducing system. This reduction was performed without cleavage of resin bound substrates from the nucleophile sensitive linker.