Reduction of steroidal ketones and enones by sodium dithionite in presence of phase transfer catalyst

Article abstract of DOI:10.1080/00397919208020484

Sodium dithionite has been effectively used in the reduction of steroidal ketones and enones with remarkable selectivity and high yields under phase transfer catalysis (PTC) conditions to give alcohols and ketones respectively. An application of these selectivities is demonstrated by reducing an important steroid intermediate 16-dehydropregnenolone acetate to pregnenolone acetate in very high yields.

Full text of DOI:10.1080/00397919208020484

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Synthetic Communications: An
International Journal for Rapid
Communication of Synthetic
Organic Chemistry
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Reduction of Steroidal Ketones
and Enones by Sodium
Dithionite in Presence of Phase
Transfer Catalyst
Akamanchi K. G. a , Patel H. C a & Meenakshi R. a
a Pharmaceuticals and Fine Chemicals Division,
Dept. of Chemical Technology , University of
Bombay , Matunga, Bombay, 400 019, India
Published online: 23 Sep 2006.
To cite this article: Akamanchi K. G. , Patel H. C & Meenakshi R. (1992) Reduction
of Steroidal Ketones and Enones by Sodium Dithionite in Presence of Phase
Transfer Catalyst, Synthetic Communications: An International Journal for
Rapid Communication of Synthetic Organic Chemistry, 22:12, 1655-1660, DOI:
10.1080/00397919208020484
To link to this article: http://dx.doi.org/10.1080/00397919208020484
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