Antitumour activity of S-p-bromobenzylglutathione cyclopentyl diester in vitro and in vivo. Inhibition of glyoxalase I and induction of apoptosis

Article abstract of DOI:10.1016/0006-2952(96)00059-7

The glyoxalase I inhibitor diester, S-p-bromobenzyl-glutathione cyclopentyl diester (BrBzGSHCp₂), inhibited the growth of human leukaemia 60 (HL60) cells in vitro. The median growth inhibitory concentration GC₅₀ value of BrBzGSHCp