Russian Journal of Bioorganic Chemistry p. 225 - 230 (2011)
Update date:2022-08-17
Topics:
Khomutov
Hyvoenen
Simonian
Vepsaelaeinen
Alhonen
Kochetkov
Keinaenen
Earlier unknown 1,8-diamino-3-methyl-4-azanonane (γ-MeSpd) was synthesized. The analogue was a substrate of neither spermine/spermidine N 1-acetyltransferase nor spermine synthase, but was capable to support the growth of DU145 cells having depleted polyamine pools. Such a combination of γ-MeSpd properties discloses novel opportunities to study cellular functions of catabolically unstable and easily interconvertible spermine and spermidine.
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