Selective cleavage of tert-butyl esters in the presence of tert-butyl ethers. Application to the synthesis of tert-butoxy amino acids

Article abstract of DOI:10.1055/s-1996-4408

We report on the selective cleavage of tert-butyl esters in the presence of tert-butyl ether groups by using trimethylsilyl triflate. The method is especially useful for the synthesis of tert-butyl ethers of N-protected hydroxy amino acids which are valuable building blocks for peptide synthesis.